Patrick Dempsey

Over 10 years after Patrick Dempsey exited Grey’s Anatomy when his iconic character Dr. Derek Shepherd died, he reflected on his connection to the series and where he stands with it now. 

March 17, 2026

After ‘Grey’s Anatomy’ star Eric Dane died at 53 on Feb.19 following a battle with ALS, we're looking back at his 2007 interview for ‘E! True Hollywood Story: Patrick Dempsey.’ Hear him chat about how the show changed his life and how his friendship began with Patrick Dempsey.

February 20, 2026

Patrick Dempsey shared that he and Eric Dane had spoken a week before his former ‘Grey's Anatomy’ costar died at the age of 53 following a battle with ALS.

February 20, 2026

Patrick Dempsey shared that he and Eric Dane had spoken a week before his former Grey's Anatomy costar died at the age of 53 following his battle with ALS.

February 20, 2026

February 3, 2026

Eric Dane’s 'Grey’s Anatomy' costar Patrick Dempsey shared that he has kept in touch with the 'Euphoria' actor amid his battle with Lou Gehrig’s disease, explaining that it’s “very hard for him.”

January 29, 2026

Eric Dane’s Grey’s Anatomy costar Patrick Dempsey shared that he has kept in touch with the Euphoria actor amid his battle with Lou Gehrig’s disease, explaining that it’s “very hard for him.”

January 29, 2026

Patrick Dempsey revealed his and Jillian Dempsey’s twin sons, Darby and Sullivan, graduated high school with a sweet family photo.

June 2, 2025

Isaiah Washington says that Sandra Oh orchestrated his comeback to 'Grey’s Anatomy' following his 2007 firing for an altercation with Patrick Dempsey and T.R. Knight.

April 25, 2025

Would you lie with E! and just forget the world as we recount Grey's Anatomy's most heart-wrenching romances—including the Meredith Grey-Derek Shepherd pairing that breathed life into the ABC hit.

March 27, 2025

'Grey’s Anatomy' creator Shonda Rhimes is looking back on the scandals that nearly ended the medical drama in its early days, including Isaiah Washington’s use of a homophobic slur.

March 21, 2025

Appearing on the March 19th episode of Alex Cooper’s ‘Call Her Daddy’ podcast, Ellen Pompeo reflected on the ‘Grey’s Anatomy’ sex scene with an unexpected character that was the most “uncomfortable” and “awkward” amid the show’s 20-plus seasons.

March 19, 2025

Amy Adams charmed audiences as Princess Giselle in Disney's Enchanted and the 2022 follow-up Disenchanted. But did you know she almost lost the role to these A-list stars?

November 21, 2024

Patrick Dempsey and his wife, Jillian Dempsey, rang in their milestone anniversary with touching tributes and throwback wedding photos. 

August 1, 2024

Patrick Dempsey’s eldest daughter Talula is frosting her own path for the future after a recent career move.

July 24, 2024

Patrick Dempsey was joined by his wife and three children at the premiere of Ferrari in Los Angeles, marking the first time his whole family has joined him at a red carpet event in three years.

December 16, 2023

December 16, 2023

Patrick Dempsey attends the premiere of his new film 'Ferrari' on Dec. 12 in Los Angeles, alongside his wife Jillian Dempsey and their three kids.

December 15, 2023

While Amy Adams charmed audiences as a Disney princess in Enchanted, the Oscar nominee was almost passed over for the role. Check out more secrets about the 2007 movie.

November 24, 2023

Patrick Dempsey was officially named People's "Sexiest Man Alive" during "Jimmy Kimmel Live." Watch to see the milestone moment!

November 8, 2023

Patrick Dempsey is adding a new title to his résumé: He has been crowned People's Sexiest Man Alive of 2023. Read on for more details about this year's honoree.

November 8, 2023

Patrick Dempsey said he is "shocked" and "deeply saddened" after a gunman opened fire in a bar and bowling alley in his hometown of Lewiston, Maine, killing at least 18 people.

October 26, 2023