Met Éireann has issued a 24 hour Status Yellow Rain warning for 17 counties.
The warning, issued for Cavan, Monaghan, Cork, Tipperary, Waterford and all of Leinster will become active at 11pm on Tuesday, and remain in place until 11pm on Wednesday.
Met Éireann forecasters warned rain falling on already saturated ground combined with high river levels will lead to flooding, poor visibility and difficult travelling conditions.
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Meanwhile, a Status Yellow Wind warning for Wexford, Wicklow, Dublin, Meath, and Louth will come into effect at 11pm, and will remain in place until 1pm on Wednesday.
Met Éireann forecasters said strong and gusty southeasterly winds combined with high tides may lead to wave overtopping, fallen trees and loose debris, and difficult travelling conditions.
A Status Yellow - Rain/Snow warning for Donegal, Leitrim, Sligo will also come into place at 2am on Wednesday, and will remain in place until 2pm on Wednesday.
Met Éireann warned rain, which will be heavy at times and turning to sleet or snow together with strengthening winds, will lead to poor visibility and difficult travelling conditions.
In its nationwide forecast, Met Éireann said Tuesday will become wet and windy overnight with outbreaks of rain becoming widespread, possibly falling as sleet or snow at times in the west and northwest and on higher ground.
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Lows of 0C to 5C early in the night, but becoming milder from the southwest through the night. Southeasterly winds will be fresh to strong.
Wednesday will be wet and breezy with widespread outbreaks of rain and drizzle, possibly falling as sleet or snow for a time in the northwest and on higher ground.
The rain will gradually become confined to Leinster and Ulster with scattered showers following for Connacht and Munster.
Already saturated ground, together with strong onshore winds coinciding with high tides, mean that some spot and coastal flooding is likely. Highs of just 2C to 5C in the north, but of 5C to 10C elsewhere. Moderate to fresh southeasterly winds will be stronger near coasts.
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